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Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides

Nagahama, K., Veedu, R.N. and Wengel, J. (2009) Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides. Bioorganic & Medicinal Chemistry Letters, 19 (10). pp. 2707-2709.

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Synthesis of chimeric 9-mer oligonucleotides containing methylphosphonate-linkages and locked nucleic acid (LNA) monomers, their binding affinity towards complementary DNA and RNA, and their 3′-exonucleolytic stability are described. The obtained methylphosphonate-DNA/LNA chimeric oligonucleotides display similarly high RNA affinity and RNA selectivity as a corresponding 9-mer DNA/LNA chimeric oligonucleotide, but much higher resistance towards 3′-exonucleolytic degradation.

Publication Type: Journal Article
Publisher: Elsevier BV
Copyright: © 2009 Elsevier Ltd.
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