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Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications

Veedu, R.N. and Wengel, J. (2010) Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications. Chemistry & Biodiversity, 7 (3). pp. 536-542.

Link to Published Version: http://dx.doi.org/10.1002/cbdv.200900343
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Abstract

Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression.

Publication Type: Journal Article
Publisher: Wiley
Copyright: © 2010 Verlag Helvetica Chimica Acta AG, Zürich
URI: http://researchrepository.murdoch.edu.au/id/eprint/27432
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