Stepping towards highly flexible aptamers: Enzymatic recognition studies of unlocked nucleic acid nucleotides
Dubois, C., Campbell, M.A., Edwards, S.L., Wengel, J. and Veedu, R.N. (2012) Stepping towards highly flexible aptamers: Enzymatic recognition studies of unlocked nucleic acid nucleotides. Chemical Communications, 48 (44). p. 5503.
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Enzymatic recognition of unlocked nucleic acid (UNA) nucleotides was successfully accomplished. Therminator DNA polymerase was found to be an efficient enzyme in primer extension reactions. Polymerase chain reaction (PCR) amplification of a 81 mer UNA-modified DNA library was efficiently achieved by KOD DNA polymerase.
|Publication Type:||Journal Article|
|Publisher:||Royal Society of Chemistry|
|Copyright:||2012 The Royal Society of Chemistry|
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