Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes
Morihiro, K., Kodama, T., Kentefu, ., Moai, Y., Veedu, R.N. and Obika, S. (2013) Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes. Angewandte Chemie: International Edition, 52 (19). pp. 5074-5078.
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Locking up selenium: A new conformationally restricted nucleic acid with a 2′,4′-selenomethylene bridge (SeLNA) can be reversibly converted into its oxidized form (SeOLNA), and the hybridization of a modified oligonucleotide was shown to be dependent on the oxidation state. A SeLNA-modified molecular-beacon-type probe (see scheme; F=fluorophore, Q=quencher) can be used as a sensor for changes in the redox environment.
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