Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo
Coles, D.J., Rolfe, B.E., Boase, N.R.B., Veedu, R.N. and Thurecht, K.J. (2013) Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo. Chemical Communications, 49 (37). pp. 3836-3838.
*Subscription may be required
Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer) while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.
|Publication Type:||Journal Article|
|Publisher:||Royal Society of Chemistry|
|Item Control Page|