Sporadic inclusion-body myositis: Clinical symptoms, physical findings, and diagnostic investigations
Mastaglia, F.L. (2011) Sporadic inclusion-body myositis: Clinical symptoms, physical findings, and diagnostic investigations. In: Askanas, V. and Engel, W.K., (eds.) Muscle Aging, Inclusion-Body Myositis and Myopathies. Wiley-Blackwell, pp. 159-167.
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Sporadic inclusion-body myositis (s-IBM) usually presents after the age of 40 years and is the most important myopathy associated with aging. The clinical phenotype is characterized by a differential pattern of muscle involvement in the upper and lower limbs and dysphagia due to involvement of the pharyngeal muscles is common. Biochemical and electrodiagnostic studies and muscle magnetic resonance imaging may be helpful when the diagnosis of s-IBM is suspected. The condition can be misdiagnosed as amyotrophic lateral sclerosis on the basis of the clinical and electromyographic findings, and a muscle biopsy is essential for definitive confirmation of the diagnosis of s-IBM. It is important that there should be greater awareness of the early symptoms of the disease so that it can be diagnosed at an early stage when the condition may be more amenable to treatment.
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