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Inclusion body myositis: Current pathogenetic concepts and diagnostic and therapeutic approaches

Needham, M. and Mastaglia, F.L. (2007) Inclusion body myositis: Current pathogenetic concepts and diagnostic and therapeutic approaches. The Lancet Neurology, 6 (7). pp. 620-631.

Link to Published Version: http://dx.doi.org/10.1016/S1474-4422(07)70171-0
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Abstract

Inclusion body myositis is the most common acquired muscle disease in older individuals, and its prevalence varies among countries and ethnic groups. The aetiology and pathogenesis of sporadic inclusion body myositis are still poorly understood; however genetic factors, ageing, and environmental triggers might all have a role. Unlike other inflammatory myopathies, sporadic inclusion body myositis causes slowly progressing muscular weakness and atrophy, it has a distinctive pattern of muscle involvement, and is unresponsive to conventional forms of immunotherapy. This review covers the clinical presentation, diagnosis, treatment, and the latest information on genetic susceptibility and pathogenesis of sporadic inclusion body myositis...

Publication Type: Journal Article
Publisher: Elsevier
Copyright: © 2007 Elsevier Ltd.
URI: http://researchrepository.murdoch.edu.au/id/eprint/25399
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