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Studies on failure of T strain live Babesia bovis vaccine

Bock, R.E., Vos, A.J., Lew, A., Kingston, T.G. and Fraser, I.R. (1995) Studies on failure of T strain live Babesia bovis vaccine. Australian Veterinary Journal, 72 (8). pp. 296-300.

Link to Published Version: http://dx.doi.org/10.1111/j.1751-0813.1995.tb03558...
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Abstract

Field investigations of the protection afforded by the Australian live Babesia bovis vaccine used in the early 1990s (T strain) revealed inadequate vaccine-induced protection in certain herds. Vaccination/challenge trials using 207 experimental cattle were conducted to evaluate the protection afforded by T strain B bovis against field isolates from these herds. The trials investigated whether isolates that could ‘break-through’ T strain immunity were present in the field, the ability or inability of specific cattle to develop protective immunity after vaccination with T strain and the effect of attenuation and maintenance procedures on the immunogenicity of T strain.

The results showed that B bovis parasites present early in the process of attenuation of T strain were more protective than those remaining late in the process. They also showed that cattle from properties experiencing vaccine failures were less protected by T strain vaccination than Bos taurus cattle randomly selected from the general population if vaccinated with highly attenuated T strain. A hypothesis is offered to explain these findings.

Publication Type: Journal Article
Publisher: Wiley-Blackwell
URI: http://researchrepository.murdoch.edu.au/id/eprint/25375
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