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Absence of a set of plasmid-encoded genes is predictive of reduced pathogenic potential in Brachyspira hyodysenteriae

La, T., Phillips, N.D., Thomson, J.R. and Hampson, D.J. (2014) Absence of a set of plasmid-encoded genes is predictive of reduced pathogenic potential in Brachyspira hyodysenteriae. Veterinary Research, 45 (1).

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Link to Published Version: http://dx.doi.org/10.1186/s13567-014-0131-6
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Abstract

The gene content of 14 strains of the intestinal spirochaete Brachyspira hyodysenteriae was compared using a DNA microarray. A consistent difference occurred in a block of four genes on the ~36 Kb plasmid, with these being present in six virulent strains and absent in eight strains with reduced pathogenic potential. These genes encoded a predicted radical S-adenosylmethionine domain protein, a glycosyl transferase group 1-like protein, an NAD dependant epimerase and a dTDP-4-dehydrorhamnose 2–5 epimerase: they may be involved in rhamnose biosynthesis and glycosylation. The absence of these plasmid genes in B. hyodysenteriae isolates is predictive of reduced pathogenic potential.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary and Life Sciences
Publisher: BioMed Central
Copyright: © 2014 La et al.
URI: http://researchrepository.murdoch.edu.au/id/eprint/24971
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