Choline chloride in the treatment of cerebellar and spinocerebellar ataxia
Livingstone, I.R., Mastaglia, F.L., Pennington, R.J.T. and Skilbeck, C. (1981) Choline chloride in the treatment of cerebellar and spinocerebellar ataxia. Journal of the Neurological Sciences, 50 (2). pp. 161-174.
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The use of orally administered choline chloride in the treatment of cerebellar and spinocerebellar ataxia was investigated by a short-term double-blind crossover trial in 20 patients with ataxia. These patients, who included 7 with Friedreich's ataxia, 7 with mixed spinocerebellar ataxia and 6 with primary cerebellar degeneration received placebo and 6 g/day or 12 g/day of choline with crossover at 6 weeks. Serum choline levels were measured 1 h after the first daily dose. Mild but significant improvement in upper limb co-ordination was noted in 3 patients with Friedreich's ataxia, 3 with mixed ataxia and 4 patients with primary cerebellar degeneration. Improvement in gait and lower limb co-ordination was observed in only 2 patients (one with cerebellar ataxia and 1 with mixed ataxia). There was no correlation between serum choline levels and clinical response to choline.
Choline chloride produces a mild but functionally significant improvement in motor co-ordination in some patients with cerebellar and spinocerebellar ataxia.
|Publication Type:||Journal Article|
|Copyright:||© 1981 Elsevier B.V.|
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