Catalog Home Page

Galactocerebroside antiserum causes demyelination of cat optic nerve

Carroll, W.M., Jennings, A.R. and Mastaglia, F.L. (1985) Galactocerebroside antiserum causes demyelination of cat optic nerve. Brain Research, 330 (2). pp. 378-381.

Link to Published Version: http://dx.doi.org/10.1016/0006-8993(85)90702-4
*Subscription may be required

Abstract

A model of immune-mediated optic nerve demyelination is described. Micro-injection of small volumes (< 5 μl) of high titer polyclonal anti-Gal-C serum into the cat optic nerve resulted in a focal, highly selective demyelinative lesion followed by remyelination. Demyelination appears to be due to a dual effect of myelin and on oligadendrocytes. The numbers of these cels within the lesion were initially reduced but subsequently increased as remyelination occured.

Publication Type: Journal Article
Publisher: Elsevier BV
Copyright: © 1985 Published by Elsevier B.V.
URI: http://researchrepository.murdoch.edu.au/id/eprint/24295
Item Control Page Item Control Page