Depot-glucagon in the treatment of McArdle's disease
Day, T.J. and Mastaglia, F.L. (1985) Depot-glucagon in the treatment of McArdle's disease. Australian and New Zealand Journal of Medicine, 15 (6). pp. 748-750.
Glucagon has been reported to improve exercise tolerance in some patients with myophosphorylase deficiency (McArdle's disease) but a placebo effect was not excluded in previous trials. A single-blind controlled trial of glucagon in a patient with myophosphorylase deficiency is described. Although an improved exercise endurance of the forearm muscles was demonstrated with both short-acting and depot-glucagon, this was not statistically significant when compared with placebo or no treatment.
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