Neutrophil function in duchenne muscular dystrophy
Karagol, U., Gardner-Medwin, D. and Mastaglia, F.L. (1986) Neutrophil function in duchenne muscular dystrophy. Journal of the Neurological Sciences, 73 (1). pp. 73-77.
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Spontaneous migration, chemotactic and bactericidal activity and nitrobluetetrazolium (NBT) reduction by neutrophils from patients with Duchenne muscular dystrophy were evaluated using quantitative techniques. Significant reductions in spontaneous migration and chemotaxis were found in the DMD group when compared with a control group of subjects. No significant differences were found in bactericidal activity or NBT reduction. The findings suggest that there is a defect in the contractile system or cell membrane function of neutrophils in DMD and that the genetic defect is expressed in leucocytes as well as other tissues.
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