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Untranslated gene regions and other Non-coding elements: Regulation of eukaryotic gene expression

Barrett, L.W., Fletcher, S. and Wilton, S.D. (2013) Untranslated gene regions and other Non-coding elements: Regulation of eukaryotic gene expression. Springer, Dordrecht, NL.

Link to Published Version: http://dx.doi.org/10.1007/978-3-0348-0679-4
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Abstract

There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.​

Publication Type: Book
Murdoch Affiliation: Centre for Comparative Genomics
Publisher: Springer
Copyright: 2013 The Authors
Notes: Series Title: SpringerBriefs in Biochemistry and Molecular Biology; ISSN: 2211-9353
URI: http://researchrepository.murdoch.edu.au/id/eprint/23589
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