Butyrylcholinesterase K variant and Alzheimer's disease
Panegyres, P.K., Mamotte, C.D.S., Vasikaran, S.D., Wilton, S., Fabian, V. and Kakulas, B.A. (1999) Butyrylcholinesterase K variant and Alzheimer's disease. Journal of Neurology, 246 (5). pp. 369-370.
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This study attempted to corroborate findings on the association between butyrylcholinesterase K variant and Alzheimer’s disease. This was performed on an autopsy-confirmed series of patients with Alzheimer’s disease and controls. The butyrylcholinesterase K variant was found to be of increased allele frequency in patients with sporadic Alzheimer’s disease. When related to APOE ɛ4 typing the association was specific but not sensitive for the diagnosis of Alzheimer’s disease.
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