Role of neuregulin-1β in dexamethasone-enhanced surfactant synthesis in fetal type II cells
King, G., Maker, G.L., Berryman, D., Trengove, R.D. and Cake, M.H. (2014) Role of neuregulin-1β in dexamethasone-enhanced surfactant synthesis in fetal type II cells. FEBS Letters, 588 (6). pp. 975-980.
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It is well established that glucocorticoids elevate the production of fibroblast-pneumocyte factor (FPF), which induces type II cells to synthesize surfactant phospholipids. FPF, however, has not been identified and it is not clear whether it is a single factor or a complex mixture of factors. In this study it has been shown that, when lung fibroblasts are exposed to dexamethasone, the concentration of neuregulin-1β (NRG1β) in conditioned medium is elevated 2-fold (P < 0.05), even though NRG1β gene expression is unaffected. This, together with the finding that exposure of type II cells to NRG1β directly stimulates by 3-fold the rate of phospholipid synthesis (P < 0.05), suggests that NRG1β is a component of FPF that promotes lung development.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary and Life Sciences|
|Copyright:||© 2014 Federation of European Biochemical Societies|
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