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Involvement of organic molybdenum compounds in the interaction between copper, molybdenum, and sulfur

Alien, J.D. and Gawthorne, J.M. (1986) Involvement of organic molybdenum compounds in the interaction between copper, molybdenum, and sulfur. Journal of Inorganic Biochemistry, 27 (2). pp. 95-112.

Link to Published Version: http://dx.doi.org/10.1016/0162-0134(86)80011-3
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Abstract

The effect on Cu metabolism of two organic Mo compounds, cysteine-Mo (CM) and cysteine-Mo-S (CMS), and of an inorganic compound, tetrathiomolybate (TTM), was investigated in sheep. Intravenous administration of CMS or TTM increased total plasma Cu concentrations and promoted the appearance of trichloroacetic acid (TCA)-insoluble Cu in plasma. Plasma Mo was increased by both compounds. Column chromatography of plasma showed that CMS caused the accumulation of TCA-insoluble Cu in high-MW fractions, whereas TTM increased the Cu content oflow-MW fractions, mainly albumin. CMS and TTM increased the concentration of Cu and Mo in kidney. In liver, Mo concentrations were elevated by both CMS and TTM, and Cu concentrations were reduced by TTM when it was given at a low dose rate. The subcellular distribution of Cu and Mo in liver and kidney was investigated. The findings are discussed in relation to the proposal that Mo-containing, organic compounds are intermediaries in the interaction between Cu, Mo, and S in ruminants.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary Studies
Publisher: Elsevier BV
URI: http://researchrepository.murdoch.edu.au/id/eprint/20666
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