Copper-histidine ternary complex equilibria with glutamine, asparagine and serine. The implications for computer-simulated distributions of copper(II) in blood plasma
Berthon, G., Hacht, B., Blais, M-J and May, P.M. (1986) Copper-histidine ternary complex equilibria with glutamine, asparagine and serine. The implications for computer-simulated distributions of copper(II) in blood plasma. Inorganica Chimica Acta, 125 (4). pp. 219-227.
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The use of computer simulation techniques for assessing the percentage distribution of metal ions in biological fluids has recently been questioned on the grounds of observed discrepancies between such simulations and the results obtained experimentally by Neumann and Sass-Kortsak in their pioneering work on low-molecular-weight copper in reconstituted human serum. Recent work by our group has resolved the most serious of these discrepancies, but some worrying uncertainties remain regarding the ternary equilibria of copper(II) and histidine with glutamine, serine and asparagine.
This paper describes an experimental investigation of these equilibria and the effect that the newly-determined data have on the computer-simulated distribution of copper(II) in blood plasma. Simulations have also been performed using the actual low-molecular-weight compositions of the biofluids studied by Neumann and Sass-Kortsak. The results show good agreement between calculated and experimentally observed distributions and confirm the usefulness of the simulation techniques.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Chemical and Mathematical Science|
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