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An immunohistochemical study of canine disseminated aspergillosis

Day, M.J. and Penhale, W.J. (1991) An immunohistochemical study of canine disseminated aspergillosis. Australian Veterinary Journal, 68 (12). pp. 383-386.

Link to Published Version: http://dx.doi.org/10.1111/j.1751-0813.1991.tb03103...
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Abstract

An Immunohistochemical study of 25 lesions from 7 dogs with disseminated aspergillosis (Aspergillus terreus) is presented. All had multiple fungal granulomas in many viscera, with centres of necrotic tissue and hyphal elements surrounded by a mixed infiltrate of predominantly mononuclear cells.

Within these lesions, hyphae coated with immunoglobulin (IgG, IgM, IgA) and complement (C3, C4) were identified, together with perl-lesional mononuclear cells that reacted with antisera directed towards either IgG, IgM, IgA or a T lymphocyte marker (MUII).

A conspicuous feature was the prominent hyphal fluorescence seen with IgA and C3 antisera. The IgA reagent also marked large numbers of mononuclear cells both around lesions and scattered throughout Interstitial tissue, suggesting an abnormality of IgA production or regulation as a factor predisposing to this condition.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary Studies
Publisher: Wiley-Blackwell
URI: http://researchrepository.murdoch.edu.au/id/eprint/20043
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