The pathology and trace element status of the toxic milk mutant mouse
Howell, J.Mc.C. and Mercer, J.F.B. (1994) The pathology and trace element status of the toxic milk mutant mouse. Journal of Comparative Pathology, 110 (1). pp. 37-47.
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The toxic milk (tx) mouse is a mutant in which copper metabolism is abnormal. Homozygous tx adults do not show overt signs of disease, but litters born to such parents are deficient in copper and die at about 2 weeks of age unless copper is provided. The results reported here clearly indicate that adults accumulate copper in the liver, kidney, spleen, brain, muscle, serum and red blood cells. The concentration of zinc is also elevated in liver, brain and muscle. In adult animals there is damage to hepatocytes with marked changes to the nuclei. Haemolysis occurs with subsequent deposition of haemosiderin in the kidney. This mutant provides a useful model for studies of the pathogenesis and treatment of copper toxicity in animals and man.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary Studies|
|Copyright:||© 1994 Published by Elsevier Ltd.|
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