Association between the σC protein of avian reovirus and virus-induced fusion of cells
Meanger, J., Wickramasinghe, R., Enriquez, C.E. and Wilcox, G.E. (1999) Association between the σC protein of avian reovirus and virus-induced fusion of cells. Archives of Virology, 144 (1). pp. 193-197.
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Monoclonal antibodies (MAbs) against a 39 kDa (σC) protein of the avian reovirus RAM-1 strain inhibited virus-induced fusion of cells and the protein was expressed on the surface of infected cells. The fusion-inhibiting activity of the three MAbs reacting with the σC protein suggest two putative epitopes were involved: one epitope recognised by antibody 6H1 and involved in fusion of both Vero and CK cells and a second epitope recognised by antibody 1G1 involved in fusion of Vero cells but not CK cells. The activity of the MAb 6E2 was intermediate, suggesting it may have been located in an intermediate position between the two putative epitopes and inhibited fusion by steric hindrance.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary and Biomedical Sciences|
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