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Biocompatibility of synthesised nano-porous anodic Aluminium oxide membranes for use as a cell culture substrate for Madin-Darby Canine Kidneys cells: A preliminary study

Poinern, G.E.J., Ali, N., Berry, C., Singh, P., Berchmans, S. and Fawcett, D. (2012) Biocompatibility of synthesised nano-porous anodic Aluminium oxide membranes for use as a cell culture substrate for Madin-Darby Canine Kidneys cells: A preliminary study. Journal of Tissue Science & Engineering, 3 (3).

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Abstract

In this study we investigate for the first time the biomedical potential of using a membrane made from anodic aluminium oxide (AAO) for culturing the Madin-Darby Canine Kidney (MDCK) epithelial cell line. Nano-porous aluminium oxide membranes exhibit interesting properties such as high porosity, which allows the exchange of molecules and nutrients across the membrane and can be made with highly specific pore sizes that can be preselected by adjusting the controlling parameters of a temperature controlled two-step anodization process. The cellular response and interactions of the MDCK cell line with the synthesised nano-porous AAO membrane, a commercially available membrane and a glass control were assessed by investigating cell adhesion, morphology and proliferation.

Publication Type: Journal Article
Murdoch Affiliation: School of Engineering and Energy
Publisher: OMICS Publishing Group
Copyright: © 2012 Poinern GEJ, et al
Notes: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://researchrepository.murdoch.edu.au/id/eprint/17571
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