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Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability

Ouadi, A., Loussouarn, A., Morandeau, L., Remaud, P., Faivre-Chauvet, A., Webb, J. and Gestin, J-F (2004) Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability. European Journal of Medicinal Chemistry, 39 (5). pp. 467-472.

Link to Published Version: http://dx.doi.org/10.1016/j.ejmech.2004.02.009
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Abstract

A simple procedure was developed to compare chelating agents for 153Sm complexes as a preliminary step to synthesise bifunctional analogues. Several variables affecting the efficiency of complex stability were investigated, such as the pre-organisation concept, cavity size, and the nature of coordination sites. Four semi-rigid agents incorporating carboxylic and/or phosphonic groupings fixed at trans-1,2-diaminocyclohexane were evaluated for their 153Sm chelation properties, and competition studies were performed. Data on the stability of the best chelating agent compound 3: trans-cyclohexane-1,2-bis(aminomethylphosphonic)-N,N′-bis(ethyl-2- iminodiacetic acid) in human serum are presented.

Publication Type: Journal Article
Murdoch Affiliation: School of Chemical and Mathematical Science
Publisher: Elsevier Masson SAS
Copyright: © 2004 Elsevier SAS.
URI: http://researchrepository.murdoch.edu.au/id/eprint/16630
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