IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis
Xu, W., li, R., Dai, Y., Wu, A., Wang, H., Cheng, C., Qiu, W., Lu, Z., Zhong, X., Shu, Y., Kermode, A.G. and Hu, X. (2013) IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis. Journal of Neuroimmunology, 261 (1-2). pp. 87-91.
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Interleukin (IL)-22 secreting CD4+ T (Th22) cells and IL-22 are involved in the pathogenesis of autoimmune disease, but their role in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unclear. We measured the proportion of Th22, Th17, CD4+IL-22+IL-17A+ T cells and serum IL-22 in NMO and MS patients. The proportion of Th22 cells, Th17 cells and serum IL-22 were increased in patients with NMO and MS. Our findings suggest that increased Th22 cells may play an important role in the pathogenesis of NMO and MS.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||Institute for Immunology and Infectious Diseases|
|Copyright:||2013 Elsevier B.V.|
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