Lack of association of SDF-1 3'A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years
Vidal, F., Peraire, J., Domingo, P., Broch, M., Knobel, H., Pedrol, E., Dalmau, D., Viladés, C., Sambeat, M.A., Gutiérrez, C., Richart, C. and Mallal, S. (2005) Lack of association of SDF-1 3'A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years. JAIDS Journal of Acquired Immune Deficiency Syndromes, 40 (3). pp. 276-279.
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We studied the frequency of the SDF-1 3'A allelic variant (801G-->A) in a cohort of white Spaniards made up of (1) HIV-1-infected long-term nonprogressors (LTNPs) older than 16 years of age (n = 57), (2) HIV-1-infected usual progressors (UPs; n = 107), and (3) a group of healthy controls (n = 100). The mutant SDF-1 3'A allele was observed in 28% of LTNPs, 19% of UPs, and 26% of healthy controls (P = not significant). Homozygosity for the 3'A mutation was detected in 7%, 4%, and 3% of LTNPs, UPs, and healthy controls, respectively (P = not significant). Polymorphism at the SDF-1 locus is not associated with LTNP disease of longer than 16 years in Spanish HIV-1-infected patients. This effect is independent of the CCR5Delta32 allele.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||Centre for Clinical Immunology and Biomedical Statistics|
|Publisher:||Lippincott Williams & Wilkins|
|Copyright:||© 2005 Lippincott Williams & Wilkins, Inc.|
|Notes:||Simon Mallal appears on behalf of the Chemokines and Long-Term Nonprogressor Study Group|
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