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Effects of treatment with omeprazole or ranitidine on gastric squamous ulceration in racing Thoroughbreds

Lester, G.D., Smith, R.L. and Robertson, I.D. (2005) Effects of treatment with omeprazole or ranitidine on gastric squamous ulceration in racing Thoroughbreds. Journal of the American Veterinary Medical Association, 227 (10). pp. 1636-1639.

Link to Published Version: http://dx.doi.org/10.2460/javma.2005.227.1636
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Abstract

Objective - To compare the effects of oral administration of omeprazole and ranitidine on gastric squamous ulceration in Thoroughbreds in race training. Design - Modified crossover study. Animals - 60 Thoroughbreds in race training with gastric squamous mucosal ulceration. Procedure - Horses were randomly allocated into 3 groups. Group 1 received no treatment for 28 days followed by administration of omeprazole (4 mg/kg [1.8 mg/lb], PO, once daily) for 28 days; group 2 received omeprazole (4 mg/kg, PO, once daily) for 28 days followed by no treatment for 28 days; and group 3 received ranitidine (6.6 mg/kg [3.0 mg/lb], PO, q 8 h) for 28 days followed by administration of omeprazole (4 mg/kg, PO, once daily) for 28 days. Ulceration was assessed endoscopically at days 0, 28,42, and 56. Lesions were scored from 0 (no ulceration) to 3 (severe ulceration). Results - After the initial 28 days of treatment, the decrease in ulcer severity was significantly greater after omeprazole treatment than after ranitidine treatment. Ulcer severity decreased significantly in group 3 horses after 14 days of treatment with omeprazole. Discontinuation of omeprazole resulted in worsening of ulcer scores; however, ulcer scores at completion of the study were less than at day 0. Horses that received omeprazole after 28 days of ranitidine treatment had a further reduction in ulcer severity. Conclusions and Clinical Relevance - Omeprazole was more effective than ranitidine in healing gastric squamous ulcers in Thoroughbreds in race training. Improvement was detected by 14 days and persisted in most of the group 2 horses for at least 28 days after omeprazole treatment was discontinued.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Publisher: American Veterinary Medical Association
URI: http://researchrepository.murdoch.edu.au/id/eprint/14842
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