Matching for MHC haplotypes results in improved survival following unrelated bone marrow transplantation.
Tay, G.K., Witt, C.S., Christiansen, F.T., Charron, D., Baker, D., Herrmann, R., Smith, L.K, Diepeveen, D., Mallal, S. and McCluskey, J. (1995) Matching for MHC haplotypes results in improved survival following unrelated bone marrow transplantation. Bone Marrow Transplantation, 15 (3). pp. 381-385.
Unrelated bone marrow donor-recipient pairs were assessed retrospectively for matching of the HLA-B, -C region (beta-block) and HLA-DR, DQ region (delta block) of the major histocompatibility complex (MHC) using a new DNA-based method referred to as MHC-block typing. The method utilises non-HLA DNA polymorphisms in the MHC as markers of blocks of ancestral haplotypes. Kaplan-Meier analysis of recipients who were matched at both the beta- and delta-blocks revealed a 6 months survival of 54%. Survival was better than for patients who were matched only by conventional criteria, including SSO-typing for class II.
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|Publisher:||Nature Publishing Group|
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