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Successful treatment of macrophage activation syndrome complicating adult Still disease with anakinra

Loh, N.K., Lucas, M., Fernandez, S. and Prentice, D. (2012) Successful treatment of macrophage activation syndrome complicating adult Still disease with anakinra. Internal Medicine Journal, 42 (12). pp. 1358-1362.

Link to Published Version: http://dx.doi.org/10.1111/imj.12002
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Abstract

A previously healthy 20-year-old man presented with adult Still disease (ASD). He developed life-threatening macrophage activation syndrome (MAS), which was refractory to standard immunosuppression but responded dramatically to the IL-1 receptor antagonist anakinra. Subsequent immunological investigations included assessment of the perforin expression of natural killer (NK) cells and CD8+ T cells, which confirmed MAS.

Publication Type: Journal Article
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Publisher: Blackwell Publishing
Copyright: © 2012 The Authors
URI: http://researchrepository.murdoch.edu.au/id/eprint/12562
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