Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India
Devi, A.R., Rao, N.A. and Bittles, A.H. (1987) Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India. Journal of Medical Genetics, 24 (6). pp. 362-365.
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Consanguineous marriages are strongly favoured among the populations of South India. In a study conducted on 407 infants and children, a total of 35 genetic diseases was diagnosed in 63 persons: 44 with single gene defects, 12 with polygenic disorders, and seven with Down's syndrome. The coefficient of inbreeding of the total study group, F = 0.0414, was significantly higher than that previously calculated for the general population, F = 0.0271, and autosomal recessive disorders formed the largest single disease category diagnosed. The results suggest that long term inbreeding may not have resulted in appreciable elimination of recessive lethals and sub-lethals from the gene pool.
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