Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults
Lu, J., Huang, Y., Wang, Y., Li, Y., Zhang, Y., Wu, J., Zhao, F., Meng, S., Yu, X., Ma, Q., Song, M., Chang, N., Bittles, A.H. and Wang, W. (2012) Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults. PLoS ONE, 7 (7). e39726.
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Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||Centre for Comparative Genomics|
|Publisher:||Public Library of Science|
|Copyright:||© 2012 Lu et al|
|Notes:||This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited|
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