Updated experience of abacavir hypersensitivity genetic testing within the major histocompatibility complex (MHC): addressing diagnostic precision and predictive value

Martin, A., Nolan, D., Gaudieri, S., Almeida, C., Carvalho, F., Witt, C., Sayer, D., Nolan, R., Herrmann, S., Christiansen, F. and Mallal, S. (2003) Updated experience of abacavir hypersensitivity genetic testing within the major histocompatibility complex (MHC): addressing diagnostic precision and predictive value. In: 5th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, 8 - 11 July, Paris, France.

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Abstract

To assess the predictive value (PV) of genetic testing for abacavir hypersensitivity syndrome (HSR) in the Western Australian HIV Cohort Study, and to extend genetic mapping of genetic susceptibility locus/loci. Abacavir-specific immunological responses were assessed to improve precision of the HSR diagnostic classification, and to provide insights into possible underlying mechanisms.