Pharmacogenomics of HIV therapy: Summary of a workshop sponsored by the National Institute of Allergy and Infectious Diseases
Haas, D.W., Kuritzkes, D.R., Ritchie, M.D., Amur, S., Gage, B.F., Maartens, G., Masys, D., Fellay, J., Phillips, E., Ribaudo, H.J., Freedberg, K.A., Petropoulos, C., Manolio, T.A., Gulick, R.M., Haubrich, R., Kim, P., Dehlinger, M., Abebe, R. and Telenti, A. (2011) Pharmacogenomics of HIV therapy: Summary of a workshop sponsored by the National Institute of Allergy and Infectious Diseases. HIV Clinical Trials, 12 (5). pp. 277-285.
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Approximately 1 million people in the United States and over 30 million worldwide are living with human immunodeficiency virus type 1 (HIV-1). While mortality from untreated infection approaches 100%, survival improves markedly with use of contemporary antiretroviral therapies (ART). In the United States, 25 drugs are approved for treating HIV-1, and increasing numbers are available in resource-limited countries. Safe and effective ART is a cornerstone in the global least in part to human genetic variants that affect drug metabolism, drug disposition, and off-site drug targets. Defining effects of human genetic variants on HIV treatment toxicity, efficacy, and pharmacokinetics has far-reaching implications. In 2010, the National Institute of Allergy and Infectious Diseases sponsored a workshop entitled, Pharmacogenomics – A Path Towards Personalized HIV Care. This article summarizes workshop objectives, presentations, discussions, and recommendations derived from this meeting.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||Institute for Immunology and Infectious Diseases|
|Publisher:||Thomas Land Publishers Inc.|
|Copyright:||© 2011 Thomas Land Publishers, Inc.|
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