IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease
Price, P. and James, I. (2009) IL1A alleles associate with a virological response to antiretroviral therapy in HIV patients beginning therapy with advanced disease. AIDS, 23 (9). pp. 1173-1176.
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Among Australians treated for advanced HIV disease, a suboptimal virological response was associated with allele 2 at interleukin 1 alpha (IL1A)-889 and IL1A+4845. This is confirmed and investigated using patients from AIDS Clinical Trials Group study 384 (n = 532). Among non-African-American patients with CD4 T-cell count of ≤100 cells/μl at baseline, IL1A+4845TT was associated with poor virological outcome (P = 0.03). Differences were smaller with higher baseline CD4 T-cell counts. IL1A-889 and IL1A+4845 were not in linkage disequilibrium in African-American patients, and IL1A+4845T did not affect outcome.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||Centre for Clinical Immunology and Biomedical Statistics|
|Publisher:||Lippincott Williams & Wilkins Ltd.|
|Copyright:||© 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins|
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