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Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B12 uptake pathway

Fazen, C.H., Valentin, D., Fairchild, T.J. and Doyle, R.P. (2011) Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B12 uptake pathway. Journal of Medicinal Chemistry, 54 (24). pp. 8707-8711.

Link to Published Version: http://dx.doi.org/10.1021/jm2012547
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Abstract

hPYY(3-36) injections have shown positive effects on appetite regulations, sparking increased interest in hPYY(3-36) research. Of great interest is oral delivery of hPYY(3-36) that can achieve clinically relevant weight-loss outcomes in what would be a highly patient compliant route. Successful oral delivery of other peptides utilizing the vitamin B12 pathway has been shown but below clinically relevant levels. Herein, we present clinically relevant in vivo oral delivery of B12-hPYY(3-36) conjugates.

Publication Type: Journal Article
Murdoch Affiliation: School of Chiropractic and Sports Science
Publisher: American Chemical Society
URI: http://researchrepository.murdoch.edu.au/id/eprint/6473
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