Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35

Allsopp, C.E.M., Hill, A.V.S., Kwiatkowski, D., Hughes, A., Bunce, M., Taylor, C.J., Pazmany, L., Brewster, D., McMichael, A.J. and Greenwood, B.M. (1991) Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35. Human Immunology, 30 (2). pp. 105-109.

Abstract

In the West African population of the Gambia the class I antigen HLA-Bw53 is found at high frequency. We used the polymerase chain reaction to amplify cDNA from an individual homozygous for this allele and determined the nucleotide sequence of the polymorphic α1 and α2 domains. The HLA-Bw53 sequence is identical to HLA-B35 except for a short sequence at the 3′ end of exon 2 (encoding the α1 domain) which specifies a Bw4 rather than a Bw6 motif. This suggests an origin for HLA-Bw53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. The α2 domain shared by HLA-Bw53, -B35, and -Bw58 is particularly common in sub-Saharan Africans.