Molecular characterization of a novel, serologically detectable, HLA-C allele: Cw∗1602

Vilches, C., Herrero, M.J., de Pablo, R., Moreno, M.E., Bunce, M. and Kreisler, M. (1994) Molecular characterization of a novel, serologically detectable, HLA-C allele: Cw∗1602. Human Immunology, 41 (2). pp. 167-170.

Abstract

Cw∗1602, a novel HLA-C allele belonging to the newly assigned Cw∗16 group, has been cloned and sequenced from a Spanish Caucasoid cell expressing a “Cw6.2” phenotype. Some of the polymorphic substitutions of the new allele, and linkage disequilibrium to B51, had been predicted on the basis of previously published studies. The primary structure of Cw∗1602 is in agreement with its serologic reactivity and, in comparison with that of Cw∗1601, underlines the dimorphism of HLA-C molecules at residues 77 and 80 of the α1-domain α helix.