A correlation between HLA-C matching and donor antirecipient CTL precursor frequency in bone marrow transplantation

Barnardo, M.C.N.M., Davey, N.J., Bunce, M., Brookes, P.A., Lechler, R.I., Welsh, K.I. and Batchelor, J.R. (1996) A correlation between HLA-C matching and donor antirecipient CTL precursor frequency in bone marrow transplantation. Transplantation, 61 (9). pp. 1420-1423.

Abstract

A newly developed, reliable, DNA-based method for typing for alleles of the HLA-C locus has been applied in the context of unrelated, volunteer donors for bone marrow transplantation. Some donors matched for HLA-A, -B, -DR, and -DQ have been found to generate in vitro high frequencies of CTL reactive with the recipient's cells. Here we demonstrate that there is a highly significant correlation of the frequencies of CTL precursors and incompatibility at the HLA-C locus. These data indicate that HLA-C locus incompatibility should be avoided in unrelated donor bone marrow transplantation.