Catalog Home Page

Assessing the influence of consanguinity on congenital heart disease

Bittles, A.H. (2011) Assessing the influence of consanguinity on congenital heart disease. Annals of Pediatric Cardiology, 4 (2). pp. 111-116.

[img]
Preview
PDF - Published Version
Download (356kB) | Preview
    Link to Published Version: http://dx.doi.org/10.4103/0974-2069.84637
    *Subscription may be required
    Link to Published Version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC318096...
    *Open access, no subscription required

    Abstract

    Numerous articles have been published linking consanguineous marriage to an elevated prevalence of congenital heart disease, with ventricular septal defects and atrial septal defects the most commonly cited disorders. While initially persuasive, on closer examination many of these studies have fundamental shortcomings in their design and in the recruitment of study subjects and controls. Improved matching of cases and controls, to include recognition of the long-established community boundaries within which most marriages are contracted, and the assessment of consanguinity within specific levels and types of marital union would improve and help to focus the study outcomes. At the same time, major discrepancies between studies in their reported prevalence and types of congenital heart disease suggest an urgent need for greater standardization in the classification and reporting of these disorders.

    Publication Type: Journal Article
    Murdoch Affiliation: Centre for Comparative Genomics
    Publisher: Medknow Publications
    URI: http://researchrepository.murdoch.edu.au/id/eprint/5481
    Item Control Page

    Downloads

    Downloads per month over past year