Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens
Wikstrom, M.E. and Stumbles, P.A. (2007) Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens. Immunology and Cell Biology, 85 . pp. 182-188.
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It is widely accepted that tissue dendritic cells (DC) function as immune sentinels by alerting T cells to foreign antigen after delivering and presenting it in the draining lymph nodes. Over the last two decades, studies in animal models, particularly rodents, have demonstrated that respiratory tract DC are crucial for the adaptive immune response to inhaled antigen. Indeed, the fate of inhaled antigen is inextricably linked to the function of respiratory tract DC. In this review, we will discuss the characteristics of respiratory tract DC from mice and recent data that may help to explain their role in the fate of inhaled antigen.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary and Biomedical Sciences|
|Publisher:||Nature Publishing Group|
|Copyright:||2007 Australasian Society for Immunology Inc.|
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