Identification of two new alleles in a single Korean individual, HLA-B*1568 and HLA-DRB1*1208
Sheldon, M.H., Bunce, M., Dunn, P.P.J., Day, S., Lee, G.D., Park, Y-J., Bang, B.K., Kim, B.K. and Oh, E-J. (2002) Identification of two new alleles in a single Korean individual, HLA-B*1568 and HLA-DRB1*1208. Tissue Antigens, 59 (5). pp. 430-432.
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We have identified a new HLA-B*15 allele and a new HLA-DRB1*12 allele, named B*1568 and DRB1*1208, respectively. The alleles were identified using a combination of sequence specific primers, reverse line sequence specific oligonucleotide probing and sequence-based typing. Both alleles were identified in a single individual of Korean origin. HLAB*1568 appears to be an HLA-B*4801/B*1507 hybrid combining the exon 2 sequence of B*4801 and the exon 3 and 4 sequences of B*1507. Exon 2 of DRB1*1208 was most similar to DRB1*1201 or 1206, with a single mismatch at nucleotide position 165 (A to C). At the protein level, this substitution results in a phenylalanine substitution at position 26 that creates an identical amino acid sequence to DRB3*0202 between amino acid positions 17 and 36.
|Publication Type:||Journal Article|
|Copyright:||© 2002 Blackwell Munksgaard|
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