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Bovine immunodeficiency virus produces a transient viraemic phase soon after infection in Bos javanicus

McNab, T., Desport, M., Tenaya, I.W.M., Hartaningsih, N. and Wilcox, G.E. (2010) Bovine immunodeficiency virus produces a transient viraemic phase soon after infection in Bos javanicus. Veterinary Microbiology, 141 (3-4). pp. 216-223.

Link to Published Version: http://dx.doi.org/10.1016/j.vetmic.2009.09.012
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Abstract

Infection of Bali cattle (Bos javanicus) in Indonesia with a non-pathogenic bovine lentivirus similar to Bovine immunodeficiency virus (BIV) is suspected but efforts to detect the virus have been unsuccessful. To define the kinetics of BIV infection in Bali cattle, 13 were infected with the R-29 strain of BIV and monitored for 60 days. No clinical effects were detected. Proviral DNA was detected in peripheral blood mononuclear cells from 4 to 60 days with peak titres 20 days post-infection (dpi). There was a transient viraemia from 4 to 14 dpi with a maximum titre of 1 × 104 genome copies/ml plasma. An antibody response to the transmembrane (TM) glycoprotein commenced 12 dpi but an antibody response to the capsid (CA) protein was detected in one animal only and not until 34 dpi. The results indicated that detection of BIV in infected Bali cattle would have a greater chance of success soon after infection and prior to the onset of a CA antibody response.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Publisher: Elsevier BV
Copyright: Crown Copyright © 2009
URI: http://researchrepository.murdoch.edu.au/id/eprint/3893
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