Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi
Holloway, G.A., Parisot, J.P., Novello, P.M., Watson, K.G., Armstrong, T., Thompson, R.C.A., Street, I.P. and Baell, J.B. (2010) Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi. Bioorganic & Medicinal Chemistry Letters, 20 (6). pp. 1816-1818.
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A benzhydryl tropinone oxime that is potently toxic to Trypanosoma cruzi has been previously identified. An SAR investigation determined that no part of the original compound was superfluous and all early SAR probes led to significant drops in activity. The only alteration that could be achieved without loss of activity was replacement of the aryl chloride substituent with chloro homologues. This led to the discovery of a trifluoromethyl-containing analogue with an EC50 against T. cruzi of 30 nM and a cytotoxicity selectivity index of over 1000 relative to rat skeletal myoblast L-6 cells.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary and Biomedical Sciences|
|Copyright:||© 2010 Elsevier Ltd.|
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