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Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia

Parameswaran, N., Thompson, R.C.A., Sundar, N., Pan, S., Johnson, M., Smith, N.C. and Grigg, M.E. (2010) Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia. International Journal for Parasitology, 40 (6). pp. 635-640.

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    Link to Published Version: http://dx.doi.org/10.1016/j.ijpara.2010.02.008
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    Abstract

    Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (B1, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at B1, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia's isolation may have favoured the persistence of non-archetypal ancestral genotypes.

    Publication Type: Journal Article
    Murdoch Affiliation: School of Veterinary and Biomedical Sciences
    Publisher: Elsevier BV
    Copyright: © 2010 Elsevier B.V.
    URI: http://researchrepository.murdoch.edu.au/id/eprint/3682
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