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Vitamin B12 in drug delivery: breaking through the barriers to a B12bioconjugate pharmaceutical

Clardy, S.M., Allis, D.G., Fairchild, T.J. and Doyle, R.P. (2011) Vitamin B12 in drug delivery: breaking through the barriers to a B12bioconjugate pharmaceutical. Expert Opinion on Drug Delivery, 8 (1). pp. 127-140.

Link to Published Version: http://dx.doi.org/10.1517/17425247.2011.539200
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Abstract

Importance of the field: Vitamin B12 (B12) is a rare and vital micronutrient for which mammals have developed a complex and highly efficient dietary uptake system. This uptake pathway consists of a series of proteins and receptors, and has been utilized to deliver several bioactive and/or imaging molecules from 99mTc to insulin. Areas covered in this review: The current field of B12-based drug delivery is reviewed, including recent highlights surrounding the very pathway itself. What the reader will gain: Despite over 30 years of work, no B12-based drug delivery conjugate has reached the market-place, hampered by issues such as limited uptake capacity, gastrointestinal degradation of the conjugate or high background uptake by healthy tissues. Variability in dose response among individuals, especially across ageing populations and slow oral uptake (several hours), has also slowed development and interest. Take home message: This review is intended to stress again the great potential, as yet not fully realized, for B 12-based therapeutics, tumor imaging and oral drug delivery. This review discusses recent reports that demonstrate that the issues noted above can be overcome and need not be seen as negating the great potential of B 12 in the drug delivery field.

Publication Type: Journal Article
Murdoch Affiliation: School of Chiropractic and Sports Science
Publisher: Ashley Publications Ltd.
Copyright: © Informa UK, Ltd.
URI: http://researchrepository.murdoch.edu.au/id/eprint/3665
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