Halogenated Cyclic Peptides Isolated from the SpongeCorticiumsp.

Laird, D.W., LaBarbera, D.V., Feng, X., Bugni, T.S., Harper, M.Kay and Ireland, C.M. (2007) Halogenated Cyclic Peptides Isolated from the SpongeCorticiumsp. Journal of Natural Products, 70 (5). pp. 741-746.

Abstract

Fractionation of two Fijian specimens of the sponge Corticium sp. led to the isolation of the known active alkaloid steroid plakinamine A and two new halogenated cyclic peptides, corticiamide A (1) and cyclocinamide B (2). Structural elucidation of 1 and 2 was achieved by an extensive combination of high-field NMR and HRFT MS/MS experiments, and the absolute stereochemistry of 2 was determined by acid hydrolysis and Marfey's analysis. Corticiamide A (1) and cyclocinamide B (2) represent the first peptides to be described from the genus Corticium.