In vitro analysis of the TAT protein transduction domain as a drug delivery vehicle in protozoan parasites
Chin Lee, S.H., Jefferies, R., Watt, P., Hopkins, R.M., Sotzik, F., Reid, S., Armson, A., Boxell, A. and Ryan, U. (2008) In vitro analysis of the TAT protein transduction domain as a drug delivery vehicle in protozoan parasites. Experimental Parasitology, 118 (3). pp. 303-307.
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The present study was undertaken to analyse the capability of HIV-1 derived TAT protein transduction domain (PTD) fused with Green Fluorescent Protein (TAT-GFP) as a delivery vehicle into a range of protozoan parasites. Successful transduction of native purified TAT-GFP was observed by fluorescent microscopy in Cryptosporidium parvum, Giardia duodenalis, and Neospora caninum. The ability to transduce peptides and other cargo into protozoan parasites, will greatly assist in the delivery of future peptide-based drugs and target validation peptides.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary and Biomedical Sciences
School of Nursing & Midwifery
|Copyright:||© 2007 Elsevier Inc.|
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