Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum
Boxell, A., Lee, S.H.C., Jefferies, R., Watt, P., Hopkins, R., Reid, S., Armson, A. and Ryan, U. (2008) Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum. Experimental Parasitology, 119 (2). pp. 301-303.
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This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite cell membrane for multiple life-cycle stages. The successful transduction may aid in target validation and the delivery of future peptide-based drugs against this important human pathogen.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary and Biomedical Sciences
School of Nursing & Midwifery
|Copyright:||© 2008 Elsevier Inc.|
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