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Synthesis of mono and Bis[60]fullerene-based dicationic peptoids

Jennepalli, S., Hammer, K.A., Riley, T.V., Pyne, S.G. and Keller, P.A. (2015) Synthesis of mono and Bis[60]fullerene-based dicationic peptoids. European Journal of Organic Chemistry, 2015 (1). pp. 195-201.

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Increasing numbers of biological applications of fullerenyl amino acids and their derivatives encouraged us to synthesise [60]fullerenyldihydropyrrole peptides, prepared from the coupling of mono- and bis[60]fullerenyldihydropyrrolecarboxylic acids 4, 5 and 41 with presynthesised peptides 13, 16, 24, 28, 29 and 46. The resulting hydrophobic scaffolded di- and tetra-cationic derivatives were tested against Staphylococcus aureus NCTC 6571 and Escherichia coli NCTC 10418. The synthesis, characterisation and biological results are discussed in this paper.

Publication Type: Journal Article
Publisher: Wiley-VCH Verlag
Copyright: © 2014 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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