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Cutting edge tools for phenotyping and characterising T-Cell subsets

Chopra, A., Gaudieri, S., Pilkington, M., Blinco, J., Leary, S., Cooper, D., Abana, C., Watson, M., Kalams, S. and Mallal, S. (2016) Cutting edge tools for phenotyping and characterising T-Cell subsets. In: Science on the Swan 2016, 2 - 5 May 2016, Perth, Western Australia.

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Next generation Sequencing (NGS) has enabled high throughput analysis of T cell receptor (TCR) repertoires, which are useful for monitoring antigen- specific T cell responses. Integrating TCR sequencing with expression levels of genes that characterise T cell phenotype at the single cell level allows comprehensive analysis of T cell function and specificity. Single cell TCR sequencing on the Illumina platform enables the identification of paired TCR α/β chains and T cell phenotype from sorted antigen-specific T cell populations. Here we highlight novel techniques available for T cell phenotyping and TCR repertoire analysis.

Publication Type: Conference Item
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
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