Production and distribution of Exotoxin A in a dermal wound infected by Pseudomonas aeruginosa
Geerlings, P.M., Penhale, J. and Stumbles, P.A. (2010) Production and distribution of Exotoxin A in a dermal wound infected by Pseudomonas aeruginosa. In: School of Veterinary and Life Sciences Annual Postgraduate Research Day, 12 November 2010, Murdoch University.
Pseudomonas aeruginosa is an opportunistic pathogen of animals and humans, particularly those with compromised immunity such as organ transplant recipients, cystic fibrosis patients, people with AIDS and the severely burned. Clinical strains often carry genes for multiple virulence factors. Collectively these virulence factors assist the bacterium to attach, colonise and penetrate host tissue and destroy host cells. Exotoxin A (ETA) is a virulence factor that is expressed by approximately 80% of human clinical isolates. Systemic ETA kills cells in susceptible organs, including the liver and kidney, which can result in the death of the patient1,2. Using a murine full thickness skin chamber model we investigated local production and systemic distribution of ETA in a dermal wound of infection.
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